By way of a story, there is nothing new, in fact, this type of story has been done time and time again. Alice is struggling to do it all - she's part of the sandwich generation with demanding kids, a sick/elderly parent, and also a husband that not only loses his job, but develops a drinking problem. She's likable enough, and it wasn't so much what she had to deal with (Egan really pours it on thick), but how she deals with things. Readers may identify with her and find the book entertaining, or not relate to her and find the book a bit dull. Or maybe readers will be too distracted by their own busy lives and feel guilty for indulging in reading when they should be doing other things.
What was interesting to me was Alice's professional journey, I also work in publishing, but it wasn't enough to really sell the story.